Merck researchers articulate and develop an assay method for radiolabeled MSM.
Key findings: Humans and animals both metabolize DMSO to MSM in a similar fashion. Striking difference in the rates of excretion of DMSO and MSM: Excretion of oral DMSO was complete after 120 hours, whereas MSM excretion was much more prolonged, lasting 480 hours or more. Gerhards reported similar findings, but did not follow excretion past 96 hours.
Key findings: MSM protects against the adverse effects of anticholinesterase agents. Also observed tranquilizing or sedative effects due to decreased motor activity following intrapedal injection, but not oral supplementation, of MSM. Evidence of substantial similarities in actions of DMSO and MSM.
Absorption, distribution, metabolism and excretion of DMSO and MSM in rhesus monkeys.
Human plasma naturally contains both DMSO and MSM in small but significant concentrations. Although it is assumed that the presence of these agents in human plasma is the result of absorption from foodstuffs, some authors have proposed a model of DMSO (and hence, MSM) synthesis within the human organism. The authors examined blood samples from 100 volunteers and determined the naturally occurring levels of DMSO in human plasma to be between 20 and 40 ng/mL (which is equivalent to 20 to 40 parts per billion). The concentrations of MSM found in human plasma were far greater, between 700 and 1,100 ng/mL (0.7 to 1.1 ppm)
First isolation of MSM from bovine blood.